Performance Test –Dose output
Change of dose output by 1% by changing the MU settings from 100MU to 101MU for a central axis 3 x 3cm2x06 beam (600MU/min)
Similar proportional changes have been achieved for field sizes of 5 x 5cm2, 10 x 10cm2, 20 x 20cm2and dose output changes of 0.5%, 10% and 100%
Error detection capability compared to Scandidos Delta 4(Radboud UMC, Nijmengen, The Netherlands)
Various IMRT and VMAT clinical beams with induced errors: One segment/control point retraction of leaves by 10, 5 and 2mm and one segment increase of 10, 5 or 2MU
Sensitivity and specificity can be expected to be sufficient for clinical practice, and at least equal to the Scandidos Delta 4
Sensitivity and specificity can be expected to be sufficient for clinical practice, and at least equal to the Scandidos Delta 4
Simulated errors(University of Florence, Italy)
Errors were introduced to an H&N IMRT treatment composed by seven beams (gantry angles = 0°, 40°, 80°, 140°, 220°, 280°, 320°). Errors were introduced by modifying the number of delivered MU (between 1 and 3 ) and by introducing small deviations in leaf positions for each segment of each beam (mimicking an MLC bank error).
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Error detection capability compared to PTW Octavius(Azienda Provinciale per i Servizi Sanitari, Trento, Italy)
The IQM capability in recognizing errors was performed introducing deviations in 4 clinical H&N VMAT plans: 3, 5 and 10% errors on total delivered MUs and 3, 5 and 10mm MLCs shift by means of an homemade Matlab(MathWorks, Natick, MA) script. The cumulative IQM checksum value was measured and the percentage difference was calculated with respect to the non-modified plan. At the same time they obtained dose distribution maps through the PTW 2D array inserted in a rotating QA phantom (RT-smartIMRT, dose.point GmbH). The local gamma pass rates (2%/2mm) were compared to the original plan values.
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Both methods detect specifically MLC shift errors, while MUs variations were better identified by IQM. IQM shows a linear response with dose (R2=0.9995), while gamma analysis seems to have difficulty in identifying 3% and 5% MUs variations.